Charting a revolution

Charting a Manifold

We construct a nonlinear mapping from a high-dimensional sample space to a low-dimensional vector space, effectively recovering a Cartesian coordinate system for the manifold from which the data is sampled. The mapping preserves local geometric relations in the manifold and is pseudo-invertible. We show how to estimate the intrinsic dimensionality of the manifold from samples, decompose the sam...

Osteoarthrits: A revolution in treatment

Background: Glucosamine and chondroitin sulfate are integral components of articular cartilage and they have important role to the physiologic and mechanical properties of this tissue. Glucosamine is acting as the precursor of the disaccharide unit in glucosaminoglycans (GAGs) of Cartilage Materials and method: The use of glucosamine and chondroitin sulfate for the symptomatic treatment of os...

charting a path to efficiencies following a

Charting Recent Progress

Congress on Alcohol and Health is updated and submitted to Congress by the Secretary of Health and Human Services (HHS) every 3 years. This important document summarizes recent advances in alcohol research and charts current progress toward preventing and decreasing alcohol abuse and alcoholism. As well as being submitted to Congress, the report is distributed throughout the country to research...

Long-term ventilation: charting a pathway home.

Children with chronic respiratory insufficiency who require assisted ventilation are a very complex and vulnerable cohort within the growing spectrum of children with physical and developmental disabilities. Beginning in the late 1970s, technological innovation and a growing appreciation of the broader social contributions of children and adults with disabilities, facilitated the transition of ...